It is often used in osteoporosis. Your doctor or health care professional may order blood tests and other tests to see how you are doing. Specifically, Prolia works by blocking a protein called RANK. So, your bones become weak and brittle. If you miss a dose of Prolia, you should receive your injection as soon as you can. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. Osteoporosis medications and medication-related osteonecrosis of the jaw. Prolia is an injection prescribed for certain adults with osteoporosis, which These include osteonecrosis of the jawbone. Pregnancy. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). You should not receive Prolia if you are allergic to denosumab, or if you But nausea may be a symptom of side effects such as vertigo or constipation. Some people have developed unusual fractures in their thigh bone. Youll likely have questions about your condition and treatment choices. To learn more about these two drugs, check out this drug article. Its recommended that calcium and vitamin D supplements be taken Your risk for infection with Prolia may be higher if you have a weakened immune system. You can learn more about how we ensure our content is accurate and current by reading our. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. Special care may be needed. You may be interested in learning how Prolia compares to the medication Fosamax. And some of these side effects are more common with certain uses of Prolia. Continue reading, Prolia (denosumab) does increase bone density. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. These are serious. you can take. If you keep this medicine at home, store it in the original carton in a refrigerator. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. Prolia may cause serious side effects. If your dizziness doesnt go away or becomes severe, talk with your doctor. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. You do not give Prolia to yourself. These can include tingling or numbness in the hands, feet, and face. Use effective birth control while using this medicine and for at least 5 months after your last dose. Will my fracture risk come back if I stop Prolia treatment? No one in clinical trials of Prolia had to stop taking the drug due to dizziness. Use of the term female in this article refers to sex assigned at birth. Prolia also carries a warning about hypocalcemia, which is a low level of With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. You may wonder how Prolia compares with the alternative drug Reclast. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Heres some information on pregnancy, breastfeeding, and Prolia use. Available for Android and iOS devices. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. With arthritis, you have pain and inflammation of your joints. Learn about the highest quality calcium supplements here. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. Calcium has active ingredients of calcium. The drug could cause your calcium level to drop too low. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. They may also have you see your dentist. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. But if youre planning to have surgery, you may need to take a break Talk with your doctor about the best options for treating your condition. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Although very rare, Prolia can cause serious dental problems and jaw-related side effects. People need calcium for bone health and other functions. Do not stop using this medicine without first talking to your doctor. They might also recommend physical therapy, massage therapy, or using a heating pad. WebNow that Im taking Prolia, do I still need calcium and vitamin D? Prolia can cause certain side effects, some of which are more common than others. You may need to go to the hospital for treatment. If you develop serious side effects while taking Prolia, call your doctor right away. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. But weight gain may occur with other medications you take or other health conditions you have. Ask your doctor about your own risk. A special MedGuide will be given to you before each treatment. WebIn many individuals, calcium supplements are better absorbed when taken with food. This lowers your risk for bone fractures. But if you think youre having a medical emergency, call 911 or your local emergency number. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Common Usually, but it depends. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. It works with your immune system to help prevent bone loss. All information is observation-only. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Prolia isnt known to cause any harmful interactions with alcohol. This drug may decrease your body's ability to fight infection. What osteoporosis medications are there, and what side effects do they have? Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Costs of prescription drugs can vary depending on many factors. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. With low BMD your bone tissues have less mineral, which means they become weaker. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. They include bone pain, back pain, and a higher risk of certain infections. There is a potential for serious side effects to an unborn child. Below, we answer some common questions about taking Prolia. You may need to have a dental exam before you begin treatment with Prolia. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. If you have jaw pain or other mouth problems while youre using Prolia, tell your doctor or dentist. 2,4. Do not share this medicine with another person, even if they have the same symptoms you have. So, dont be afraid to ask questions or offer feedback on your treatment. Brush and floss your teeth as directed. Its thought that hair loss could occur due to how Prolia affects your immune system. Studies of Prolia didnt report weight gain as a side effect of the drug. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Some items may interact with your medicine. Different individuals may respond to medication in different ways. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. Talk with your doctor about the risks of using this drug during pregnancy. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Tell your doctor right away if you become pregnant while taking Prolia. There are no known interactions with Prolia and other medications, supplements, or other products. These side effects may be temporary, lasting a few days or weeks. Serious skin infections may occur, but are uncommon But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. If you have a male* sexual partner, they should use birth control during this time as well. Nausea can sometimes be a symptom of severe constipation. Before you have any dental work done, tell your dentist you are receiving this medicine. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Although both drugs are approved to treat similar conditions, they work in different ways. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. You may have questions about Prolia and your treatment plan. If your doctor says this is safe for you, youll be shown how to inject the medication. In rare cases, your doctor may have you self-inject Prolia at home. They can help you decide whether the possible benefits for your condition outweigh your risks for serious side effects. You should talk with your doctor if you develop any mild side effects that concern you. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Use of the term male in this article refers to sex assigned at birth. What should I know about Prolia vs. Boniva? For a detailed breakdown of Prolia versus Xgeva, check out this article. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Ask your doctor about the pros and cons of using Prolia. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Youll get Prolia injections from a healthcare professional once every 6 months. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. Take good care of your teeth and gums while you receive Prolia. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. If your levels are high, theyll typically recommend lifestyle changes and medication. For a basic overview of Prolia, including details about its uses, see this article. For more information about how Prolia and Zometa compare with each other, see this article. Patient testimonials represent individual experiences with Prolia. No, Prolia isnt a bisphosphonate. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Can you drink alcohol while taking Prolia? Xgeva is also used to treat giant cell tumor of the bone. Use effective birth control while using denosumab and for at least 5 months after your last dose. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. * Sex and gender exist on spectrums. Prolia can also cause low calcium levels. Your doctor can also advise you on symptoms of low calcium to look for. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). Web You will receive Prolia 1 time every 6 months. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Dosage of drugs is not considered in the study. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Allergic reaction. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Serious infections may occur during treatment with Prolia. Women going through menopause have a higher risk of developing osteoporosis. Call your doctor right away if you have an allergic reaction to Prolia. Find out why people need calcium, which foods provide it, and what happens if they consume. There arent any studies that have compared these two drugs to each other. Also, hair loss may be related to other medications you take or health conditions you have. MNT is the registered trade mark of Healthline Media. These medications have different active ingredients and they belong to different groups of drugs. Over time, Prolia can reduce bone loss and make your bones stronger. Do not treat yourself. They can suggest ways to help relieve these side effects. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. Side effects are possible with Prolia use, but in most cases they go away after a while. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. You should also talk with your doctor if you have nausea during treatment. But doing so can cause more bone breakdown and increase your risk for bone fractures. You should receive your missed injection as soon as possible. We avoid using tertiary references. Thyroid or parathyroid surgery. Tell your doctor if you become pregnant. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. * For more information on this side effect, see the Side effect focus section below. For women with osteoporosis after menopause at high risk for fracture. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Heres a short list of some of the mild side effects that Prolia can cause. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. Pay special attention to your dental hygiene. What do I need to be aware of if I need a tooth extraction while Im using Prolia? * Sex and gender exist on spectrums. This aids in keeping your calcium level within the recommended range. These supplements help to prevent a low calcium level while youre taking Prolia. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. It can have some side effects, but these may depend on who uses it. With osteopenia, your bone mineral density (BMD) is lower than usual. Learn how to increase or maintain bone density here. (Biosimilars are like generic drugs. Biosimilars usually cost less than brand-name drugs. We do not endorse non-Cleveland Clinic products or services. But tingling may be a symptom of side effects such as sciatica and hypocalcemia. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. Prolia can cause both mild and serious side effects. This medication guide provides information about the Prolia brand of denosumab. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. If youre breastfeeding, you should not receive Prolia. If youve already gone through menopause, your risk for bone loss is increased. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. What should I know about Prolia vs. Xgeva? This is because its not known if Prolia is safe to receive while breastfeeding. 1 shot every 6 months could mean fewer doses. Talk to your health care professional or pharmacist for more information. If you have low blood calcium, it may get worse during treatment. So, if you want to stop taking Prolia, talk with your doctor. High cholesterol itself doesnt cause any symptoms. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Low blood calcium level. Continue reading, Yes, Prolia does appear to weaken your immune system. Learn more details about some of the side effects that Prolia may cause. For more information, you can refer to the drugs prescribing information. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. And ask your doctor about which drug is right for your condition. Prolia (denosumab) injection, for subcutaneous use. * For more information about this side effect, see Side effect specifics below. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. have happened in people who take Prolia. But this isnt the case with Prolia. But Zometa contains the active drug zoledronic acid. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. Our website services, content, and products are for informational purposes only. 8,432 people who take Prolia and Calcium together, and have interactions are studied. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Prescribing Information and Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Doing so will help you avoid the risk for a low calcium level during treatment. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. But if they become bothersome, talk with your doctor or pharmacist. Prolia comes with a warning about a low level of calcium in the blood. You may also want to do some research on your own. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Q: Does AlgaePlus Increase Bone Mass? They can also happen if you have certain conditions or if you take certain medications. Tell your doctor if youd like to know more about these drugs. Theyll discuss with you other treatments to help protect you from fractures and bone loss. But its believed that these side effects are rare. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Its given to adults who are at high risk for bone fractures. Brush and floss your teeth regularly while receiving this medication. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. for breast cancer that has not spread to other parts of the body. * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Call your doctor for medical advice about side effects. Prolia also has other uses, which are described in the next section below. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. But if you think youre having a medical emergency, call 911 or your local emergency number. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. For instance: Both Prolia and Forteo are given as injections under your skin. Bring someone with you to your appointment if doing so will help you feel more comfortable. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. In addition, you should use effective birth control while youre taking Prolia. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Adults over age 50 should not exceed 2,000 mg total per day. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Prolia is a monoclonal antibody. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body.
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